Figure 1 Multiple forms of prions isolated from infected Syrian hamster brains. (A) microsomal membranes containing submicroscopic, infectious prion particles; (B) purified prion rods representing a polymeric form of the infectious prion particle and generated by limited proteolysis in the presence of detergent; (C) prion liposomes generated by sonication of infectious prion rods isolated from infected Syrian hamster (SHa) brains using limited proteolysis, detergent extraction and sedimentation through a discontinuous sucrose gradient. All three forms contain high levels of prion infectivity (>107 ID50 units/ml). Bars represent 100 nm.
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