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Type Species |
(AAV-2) |
Populations of mature virions contain equivalent numbers of positive or negative strand ssDNA 4.7 kb in size. The DNA molecules contain inverted terminal repeats of 145 nts, the first 125 nts of which form a palindromic sequence. Upon extraction, the complementary DNA strands usually form dsDNA. The are three mRNA promoters (map units 5, 19, 40). Efficient virus replication is dependent upon helper adenoviruses or herpes viruses. Under certain conditions (presence of mutagens, synchronization of cell replication with hydroxyurea), replication can also be detected in the absence of helper viruses. All AAV isolates share a common antigen as demonstrated by fluorescent antibody staining. Transplacental transmission has been observed for AAV-1 and vertical transmission has been reported for avian AAV.
List of Species Demarcation Criteria in the Genus
Criteria used to distinguish among species include biological host range and differences in structural protein antigenicity.
Official virus species names are in italics. Tentative virus species names, alternative names ( ), strains or serotypes are not italicized. Virus names, genome sequence accession numbers [ ], and assigned abbreviations ( ) are:
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Adeno-associated virus 1 |
(AAV-1) | |
|
Adeno-associated virus 2 |
[J01901] |
(AAV-2) |
|
Adeno-associated virus 3 |
[AF028705] |
(AAV-3) |
|
Adeno-associated virus 4 |
[U89790] |
(AAV-4) |
|
Adeno-associated virus 5 |
(AAV-5) | |
|
Adeno-associated virus 6 |
[AF208704] |
(AAV-6) |
|
Avian adeno-associated virus |
(AAAV) | |
|
Bovine adeno-associated virus |
(BAAV) | |
|
Canine adeno-associated virus |
(CAAV) | |
|
Equine adeno-associated virus |
(EAAV) | |
|
Ovine adeno-associated virus |
(OAAV) |
Tentative Species in the Genus
None reported.
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