Figure 1 (Top) A. Diagram of of normal isometric virus with icosahedral capsid or “core” surrounded by a coat of HBsAg. B. Tadpole-shaped virus with elongated coat. C and D. Spherical and filamentous assemblies of excess coat protein (Adapted from Stannard, L.M., Animal Virus Structure, Nermut, M.V. and Steven, A.C., Eds., Elsevier, Amsterdam, 1987, 361. With permission.) (Bottom) Negative contrast electron micrographs of Hepatitis B virus (HBV) virions (left) and virus-associated particles (center and right) together with an SDS-PAGE protein profile of each particle form to the left of the relevant micrograph. L-, M- and SHBs refer to large, middle and small HB surface proteins. HBc, hepatitis B core proteins; GP, glycoprotein; P, protein. (Courtesy W. Gerlich.)
Figure 2 Diagram of genome organization of Hepatitis B virus (HBV) indicating the molecular structure of the DNA with 5 covalent attachments to each strand, the location of the 4 ORFs (pre C/C, P, pre S/S and X). (Adapted from M. Kann and W. Gerlich.)
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