Figure 1 (Left) Schematic of mature and immature virion. (Right) Cryo-electron micrograph of mature and immature virions of Tick-borne encephalitis virus (TBEV). (Fuller et al., unpublished data). Arrows point to immature virions.
Figure 2 Flavivirus genome organization (not to scale) and polyprotein processing. At the top is the viral genome with the structural and nonstructural protein coding regions and the 5 and 3-NCRs indicated. Boxes below the genome indicate viral proteins generated by the proteolytic processing cascade. The viral structural proteins are shown in black. P, H, and R symbols indicate the localization of the NS3 proteinase, the NS3 RNA helicase, and the NS5 RNA-dependent RNA polymerase.
Figure 3 Negative contrast electron micrograph of particles of Bovine viral diarrhea virus (BVDV). The bar represents 100 nm. (From M. König, with permission.)
Figure 4 Pestivirus genome organization (not to scale) and polyprotein processing. The RNA is usually about 12.3 kb in size (depending on the virus). The 5-non-coding region (NCR) is about 372-385 nts, the ORF about 11.7 kb and the 3-NCR is 188-241 nts. P, P, H, and R symbols indicate the localization of the Npro proteinase, the NS3 proteinase, the NS3 RNA helicase, and the NS5B RNA-dependent RNA polymerase, respectively. The viral structural proteins are shown in dark. The proteinases (where known) and proteolytic steps involved in the generation of the individual proteins are indicated. In noncytopathogenic BVD viruses, NS2-3 is not cleaved. In cytopathogenic BVD viruses, NS3 is usually produced in addition to NS2-3. If NS3 production is a result of NS3 gene duplication, NS2 is not produced.
Figure 5 Hepacivirus genome organization (not to scale) and polyprotein processing. The RNA is about 9.6 kb in size. The 5-non-coding region (NCR) is about 340 nts, the 3-NCR is about 250 nts, and the ORF is about 9 kb. The proteases involved in cleavage of the polyprotein are indicated. The structural proteins are shown in dark. The locations of the proteinases, helicase and RNA-dependent RNA polymerase are indicated by P, P, H and R, respectively.
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