Table 1 Virus-associated proteins of coronaviruses
|
Protein |
Coronavirusa | |
|
Spike glycoprotein |
S |
180-220 |
|
Membrane protein |
M |
23-35 |
|
Nucleocapsid protein |
N |
50-60 |
|
Small-envelope protein |
E |
9-12 |
|
Hemagglutinin-esterase protein |
HE |
65 |
a, apparent Mr estimated by electrophoresis ( 103)
Table 2 Virus-associated proteins of toroviruses
|
Protein |
Torovirusa | |
|
Spike glycoprotein |
S |
200 |
|
Membrane protein |
M |
27 |
|
Nucleocapsid protein |
N |
19 |
|
Small-envelope protein |
E |
nk |
|
Hemagglutinin-esterase protein |
HE |
65 |
a, apparent Mr estimated by electrophoresis ( 103). nk, presence not known.
Table 3 Features of coronaviruses and toroviruses
|
Feature |
Coronavirus |
Torovirus |
|
Enveloped |
+ |
+ |
|
Linear positive-sense ssRNA with poly(A) tail |
+ |
+ |
|
5polymerase gene-structural protein genes 3 |
+ |
+ |
|
3 co-terminal nested set of 4 subgenomic mRNAs |
+ |
+ |
|
Only 5 unique region of mRNAs is translationally active |
+ |
+ |
|
Ribosomal frameshifting in the polymerase gene |
+ |
+ |
|
M protein with three membrane-spanning sequences |
+ |
+ |
|
Intracellular budding |
+ |
+ |
|
Genome size (kb) |
27-31 |
~25 |
|
5 leader sequence |
+ |
- |
|
Core shell |
+ |
- |
|
Nucleocapsid |
helical |
tubular |
|
Prominent spikes |
+ |
+ |
|
Coiled-coil structure in spikes |
+ |
+ |
|
|