DESCRIPTION OF VIRUSES

Family Coronaviridae

Table Gallery

Table Gallery

Table 1 Virus-associated proteins of coronaviruses

Protein

Coronavirusa


Spike glycoprotein

S

180-220

Membrane protein

M

23-35

Nucleocapsid protein

N

50-60

Small-envelope protein

E

9-12

Hemagglutinin-esterase protein

HE

65

a, apparent Mr estimated by electrophoresis ( 103)

Table 2 Virus-associated proteins of toroviruses

Protein

Torovirusa


Spike glycoprotein

S

200

Membrane protein

M

27

Nucleocapsid protein

N

19

Small-envelope protein

E

nk

Hemagglutinin-esterase protein

HE

65

a, apparent Mr estimated by electrophoresis ( 103). nk, presence not known.

Table 3 Features of coronaviruses and toroviruses

Feature

Coronavirus

Torovirus


Enveloped

+

+

Linear positive-sense ssRNA with poly(A) tail

+

+

5polymerase gene-structural protein genes 3

+

+

3 co-terminal nested set of 4 subgenomic mRNAs

+

+

Only 5 unique region of mRNAs is translationally active

+

+

Ribosomal frameshifting in the polymerase gene

+

+

M protein with three membrane-spanning sequences

+

+

Intracellular budding

+

+

Genome size (kb)

27-31

~25

5 leader sequence

+

-

Core shell

+

-

Nucleocapsid

helical

tubular

Prominent spikes

+

+

Coiled-coil structure in spikes

+

+