Figure 1 Negative contrast electron micrograph of virions of Human astrovirus (HAstV) from a stool specimen. The bar represents 100 nm. (Courtesy of Dr C. Humphrey.)
Figure 2 The arrangements of the genome, subgenomic RNA and deduced coding information for Human astrovirus 1 (HAstV-1) are shown. ORF1b, encoding a putative polymerase is in a different reading frame to that of ORF1a; translation involves a ribosomal frameshift.
Figure 3 Phylogenetic relationship of human and feline astrovirus species. The complete deduced amino acid sequences for ORF2 were aligned by using the pileup program of the Wisconsin Package with the Blosum62 comparison matrix. The aligned sequences were analyzed using the maximum parsimony program, PAUP, as implemented in the Wisconsin Package, with gaps treated as missing. Bootstrap values (100 replicates) are indicated on those branches which are well supported. The Newcastle and Oxford strains of Human astrovirus 1 (HAstV-1) are indicated by (N) and (O), respectively. Comparable sequence information for Human astrovirus 7 (HAstV-7) and the other animal strains is not currently available.
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