Genus Phlebovirus
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Type Species |
Rift Valley fever virus |
(RVFV) |
Distinguishing Features
The surface morphology of phleboviruses is distinct in having small round subunits with a central hole (Fig. 7). The consensus terminal nucleotide sequences of the L, M and S segments are UGUGUUUC . . . at the 3
-end and ACACAAAG . . . at the 5-end. The S RNA exhibits an ambisense coding strategy, i.e., it is transcribed by the virion RNA polymerase to a subgenomic virus-complementary sense mRNA that encodes the N protein and, from a full-length antigenome S RNA, to a subgenomic virus-sense mRNA that encodes a nonstructural (NSs) protein. The M segment of viruses in the Sandfly fever group but not viruses in the Uukuniemi group have a preglycoprotein coding region that codes for a nonstructural protein(s) (NSm). The similar sizes of the G1 and G2 proteins account for the different G1:G2 order in the M segments of different viruses. Phleboviruses are antigenically unrelated to members of other genera, but cross-react serologically among themselves to different degrees. Sandfly fever group viruses are transmitted by phlebotomines, mosquitoes or ceratopogonids of the genus Culicoides; Uukuniemi group viruses are transmitted by ticks.
List of Species Demarcation Criteria in the Genus
The lack of biochemical data for most phleboviruses dictates that the species are defined by the serological relationships, and are distinguishable by four-fold differences in two-way neutralisation tests.
List of Species in the Genus
Official virus species names are in italics. Tentative virus species names, alternative names ( ), strains or serotypes are not italicized. Under each virus species name is listed a number of other viruses of unknown exact taxonomic status. They differ from the listed virus species antigenically as well as in terms of host range vector species, geographical origins and pathogenic properties. Virus names, vector types, genome sequence accession numbers [ ], and assigned abbreviations ( ) are:
Species in the Genus
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Bujaru virus |
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(BUJV) |
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BeAn 47693 virus |
N.D. |
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(BUJV) |
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Munguba virus |
phlebotomines |
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(MUNV) |
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Chandiru virus |
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(CDUV) |
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BeH 2251 virus |
N.D. |
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(CDUV) |
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Alenquer virus |
N.D. |
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(ALEV) |
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Itaituba virus |
N.D. |
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(ITAV) |
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Nique virus |
phlebotomines |
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(NIQV) |
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Oriximina virus |
phlebotomines |
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(ORXV) |
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Turuna virus |
phlebotomines |
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(TUAV) |
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Chilibre virus |
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(CHIV) |
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Chilibre virus VP-118D |
phlebotomines |
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(CHIV) |
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Cacao virus |
phlebotomines |
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(CACV) |
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Frijoles virus |
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(FRIV) |
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Frijoles virus VP-161A |
phlebotomines |
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(FRIV) |
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Joa virus |
N.D. |
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(JOAV) |
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Punta Toro virus |
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(PTV) |
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Punta Toro virus D-4021A |
phlebotomines |
[M: M11156] |
(PTV) |
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[S: K02736] |
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Buenaventura virus |
phlebotomines |
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(BUEV) |
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Rift Valley fever virus |
mosquitoes |
[L: X56464] |
(RVFV) |
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[M: M11157] |
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[S: X53771] |
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Belterra virus |
N.D. |
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(BELTV) |
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Icoaraci virus |
phlebotomines |
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mosquitoes |
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(ICOV) |
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Salehebad virus |
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(SALV) |
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Salehebad I-81 virus |
phlebotomines |
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(SALV) |
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Arbia virus |
phlebotomines |
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(ARBV) |
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Sandfly fever Naples virus |
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(SFNV) |
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Sabin virus |
phlebotomines |
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(SFNV) |
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Karimabad virus |
phlebotomines |
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(KARV) |
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Tehran virus |
phlebotomines |
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(THEV) |
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Toscana virus |
phlebotomines |
[L: X68414] |
(TOSV) |
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[M: X89628] |
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[S: X53794] |
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Uukuniemi virus |
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(UUKV) |
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Uukuniemi virus S 23 |
ticks |
[L: D10759] |
(UUKV) |
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[M: M17417] |
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[S: M33551] |
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EgAN 1825-61 virus |
N.D. |
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(EGAV) |
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Fin V 707 virus |
N.D. |
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(FINV) |
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Grand Arbaud virus |
ticks |
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(GAV) |
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Manawa virus |
ticks |
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(MWAV) |
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Murre virus |
N.D. |
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(MURV) |
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Oceanside virus |
ticks |
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(OCV) |
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Ponteves virus |
ticks |
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(PTVV) |
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Precarious Point virus |
ticks |
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(PPV) |
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RML 105355 virus |
ticks |
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(RMLV) |
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St. Abbs Head virus |
ticks |
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(SAHV) |
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Tunis virus |
N.D. |
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(TUNV) |
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Zaliv Terpeniya virus |
ticks |
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(ZTV) |
Tentative Species in the Genus
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Aguacate virus |
phlebotomines |
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(AGUV) |
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Anhanga virus |
N.D. |
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(ANHV) |
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Arboledas virus |
phlebotomines |
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(ADSV) |
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Arumowot virus |
mosquitoes |
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(AMTV) |
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Caimito virus |
phlebotomines |
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(CAIV) |
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Chagres virus |
phlebotomines, |
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mosquitoes |
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(CHGV) |
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Corfou virus |
phlebotomines |
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(CFUV) |
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Gabek Forest virus |
N.D. |
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(GFV) |
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Gordil virus |
N.D. |
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(GORV) |
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Itaporanga virus |
mosquitoes |
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(ITPV) |
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Odrenisrou virus |
mosquitoes |
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(ODRV) |
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Pacui virus |
phlebotomines |
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(PACV) |
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Rio Grande virus |
N.D. |
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(RGV) |
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Sandfly fever Sicilian virus |
phlebotomines |
[S: J04418] |
(SFSV) |
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Saint-Floris virus |
N.D. |
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(SAFV) |
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Urucuri virus |
N.D. |
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(URUV) |
