Genus Hantavirus
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Type Species |
Hantaan virus |
(HTNV) |
Distinguishing Features
The consensus terminal nucleotide sequences of the L, M and S genome segments are AUCAUCAUCUG . . . at the 3
-end and UAGUAGUA . . . at the 5-end. Non-structural polypeptides are not encoded in any of the three genome segments. Viruses are serologically unrelated to members of other genera. Certain hantaviruses are etiologic agents of hemorrhagic fever with renal syndrome or hantavirus pulmonary syndrome (HPS). The host range of hantaviruses is primarily rodents, and genetically distinct hantaviruses are usually associated with a single rodent species. Human infection is incidental to viral maintenance and is almost always dead-end, with the exception of a recently reported human-to-human transmission of Andes virus. In contrast to other viruses in the family, hantaviruses are not transmitted by arthropods, and both rodent and human infections are acquired by aerosol exposure to infectious virus in rodent urine, feces or saliva, and less frequently by rodent bite. Hantaviruses cause no detectable cytopathology in vertebrate cell cultures and cause persistent, non-pathogenic infections of rodents. See Fig. 5.
List of Species Demarcation Criteria in the Genus
Species are found in a unique ecological niche, i.e., in a different primary rodent reservoir species or subspecies. Species exhibit at least 7% difference in amino acid identity on comparison of the complete glycoprotein precursor and nucleocapsid protein sequences. Species show at least 4-fold difference in two-way cross-neutralization tests, and species do not naturally form reassortants with other species. However, since reassortants have been generated in the laboratory between some of the listed viruses, the issue of whether these are distinct virus species is uncertain.
List of Species in the Genus
Official virus species names are in italics. Tentative virus species names, alternative names ( ), strains or serotypes are not italicized. Virus names, rodent host names, genome sequence accession numbers [ ], and assigned abbreviations ( ) are:
Species in the Genus
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Andes virus |
Oligoryzomys longicaudatus |
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(ANDV) |
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Bermejo virus |
Oligoryzomys chacoensis |
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Lechiguanas virus |
Oligoryzomys flavescens |
[M: AF028022] |
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Maciel virus |
Bolomys obscurus |
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Oran virus |
Oligoryzomys longicaudatus (?) |
[M: AF028024] |
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Pergamino virus |
Akadon azarae |
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Bayou virus |
Oryzomys palustris |
[M: L36930] |
(BAYV) |
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[S: L36929] |
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Black Creek Canal virus |
Sigmodon hispidus |
[M: L39950] |
(BCCV) |
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Cano Delgadito virus |
Sigmodon alstoni |
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(CADV) |
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Dobrava-Belgrade virus |
Apodemus flavicollis |
[M: L33685] |
(DOBV) |
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[S: L41916] |
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El Moro Canyon virus |
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(ELMCV) |
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RM-97 virus |
Reithrodontomys megalotis |
[M: U26828] |
[S: U11427] |
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Hantaan virus |
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(HTNV) |
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CUMC-B11 virus |
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[M: U38177] |
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[S: U37768] |
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Hantaan 76-118 virus |
Apodemus agrarius |
[L: X55901] |
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[M: M14627] |
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[S: M14626] |
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HoJo virus |
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[M: D00376] |
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HV114 virus |
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[M: L08753] |
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Lee virus |
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[M: D00377] |
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Isla Vista virus |
Microtus califonicus |
[S: U19302] |
(ISLAV) |
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Khabarovsk virus |
Microtus fortis |
[S: U35255] |
(KHAV) |
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Laguna Negra virus |
Calomys laucha |
[M: AF005728] |
(LANV) |
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[S: AF005727] |
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Muleshoe virus |
Sigmodon hispidus |
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(MULV) |
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New York virus |
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(NYV) |
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RI-1 virus |
Peromyscus leucopus |
[M: U36801] |
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[S: U09488] |
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Prospect Hill virus |
Microtus pennsylvanicus |
[M: X55129] |
(PHV) |
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[S: X55128] |
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Bloodland Lake virus |
Microtus ochrogaster |
[S: U19303] |
(BLLV) |
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Puumala virus |
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(PUUV) |
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1324Cg/79 virus |
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[S: Z46942] |
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Bashkiria Cg18-20 virus |
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[L: M63194] |
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[M: M29979] |
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[S: M32750] |
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K27 virus |
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[M: L08754] |
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[S: L08804] |
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Kamiiso-8Cr-95 virus |
Clethrionomys rufocanus |
[S: AB010730] |
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Kazan virus |
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[M: Z84205] |
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[S: Z84204] |
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p360 virus |
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[M: L08755] |
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[S: L11347] |
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Sotkamo virus |
Clethrionomys glareolus, |
[L: Z66548] |
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C. rufocanus |
[M: X61034] |
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[S: X61035] |
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Tobetsu-60Cr-93 virus |
Clethrionomys rufocanus |
[S: AB010731] |
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Urmurtia/338Cg/92 virus |
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[S: Z30708] |
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Vindeln/L20Cg/83 virus |
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[M: Z49214] |
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[S: Z48586] |
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Vranica virus |
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[M: U14136] |
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[S: U14137] |
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Rio Mamore virus |
Oligoyomys microtis |
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(RIOMV) |
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Rio Segundo virus |
Reithrodontomys mexicanus |
[S: U18100] |
(RIOS) |
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Seoul virus |
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(SEOV) |
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HR80-39 virus |
Rattus norvegicus |
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Rattus rattus |
[L: X56492] |
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[M: S47716] |
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Biken-1 virus |
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[M: X53861] |
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HB55 virus |
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[M: AF035832] |
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KI-83-262 virus |
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[M: D17592] |
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KI-85-1 virus |
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[M: D17593] |
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KI-88-15 virus |
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[M: D17594] |
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L99 virus |
Rattus losea |
[M: AF035833] |
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R22 virus |
Rattus norvegicus |
[M: S68035] |
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SR-11 virus |
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[M: M34482] |
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[S: M34881] |
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Sin Nombre virus |
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(SNV) |
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NMH10 virus |
Peromyscus maniculatus |
[L: L37901] |
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[M: L25783] |
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[S: L25784] |
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Blue River virus |
Peromyscus leucopus |
[M: AF030551] (Indiana) |
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[M: AF030552] (Oklahoma) |
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Convict Creek 74 virus |
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[L: L35009] |
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[M: L33684] |
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[S: L33816] |
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Convict Creek 107 virus |
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[L: L35008] |
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[M: L33474] |
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[S: L33683] |
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Monongahela virus |
Peromyscus maniculatus |
[S: U32591] |
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NMR-11 virus |
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[L: L37902] |
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[M: L37903] |
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[S: L37904] |
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Thailand virus |
Bandicota indica |
[M: L08756] |
(THAIV) |
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Thottapalayam virus |
Suncus murinus |
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(TPMV) |
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Topografov virus |
Lemmus sibiricus |
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(TOPV) |
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Tula virus |
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(TULV) |
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Moravia/Ma5302V virus |
Micotus arvalis, |
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M. rossiaemeridionalis |
[M: Z69993] |
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[S: Z69991] |
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Malacky/Ma32/94 virus |
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[S: Z48235] |
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Tentative Species in the Genus
None identified.
