Figure 1 A diagrammatic representation of the 3 to 5 arrangement of the transcriptional units in the genomes of viruses classified in the four families (Bornaviridae, Filoviridae, Paramyxoviridae and Rhadoviridae) comprising the Order Mononegavirales. Genes encoding polypeptides of presumed homologous function are aligned vertically. Abbreviations: viruses - Borna disease virus, BDV; Vesicular stomatitis virus, VSV; Sonchus yellow net virus, SYNV; Lettuce necrotic yellows virus, LNYV; Sigma virus, SiV; Rabies virus, RV; Infectious haematopoietic virus, IHNV; Bovine ephemeral fever virus, BEFV; Adelaide river virus, ARV; Ebola virus, EBOV; Measles virus, MV; Sendai virus, SeV; Mumps virus, MuV; Turkey rhinotracheitis virus, TRTV; Respiratory syncytial virus, RSV; Pneumonia virus of mice, PVM; transcriptional units - le, noncoding leader region; NS, nonstructural protein gene; N, nucleoprotein gene; P, phosphoprotein gene; V and C, dispensible non-structural protein genes; sc4, 4b and (RT), genes of unknown function; M and M1, nonglycosylated matrix protein gene; (M), glycosylated matrix protein gene; F, fusion protein gene; SH, small hydrophobic protein gene; G (or H or HN), glycosylated (or haemagglutinin or haemagglutinin/neuraminidase) attachment protein gene; M2, non-glycosylated (BDV excepted) envelope protein gene; Ps, pseudogene; NV, nonvirion protein gene; Gns, presumptive duplicated G sequence; L, large (polymerase) protein gene; tr, noncoding trailer region.
Figure 2 Phylogenetic tree constructed from the aligned A, B, C and D core polymerase motifs within domain III of the L (polymerase) proteins of fourteen different viruses belonging the families Filoviridae, Paramyxoviridae and Rhabdoviridae. The tree was constructed using the MEGA program. The figures on the branches represent the percentage of trees containing each cluster out of 500 bootstrap replicates. The branch lengths are proportional to the genetic distance between sequences. (Adapted from Pringle and Easton, 1997.)
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