Segment

ORF

Protein function

L

1

Structural framework (dodecahedron)

2

RNA polymerase active site

4

NTPase, provides the RNA packaging energy

7

packaging factor

M

3

Spikes, host attachment

6

Membrane, anchor for P3

10

Membrane, lysis

11

Membrane

S

8

Nucleocapsid surface protein

12

Envelopment of capsid, nonstructural

9

Membrane assembly

5

Endopeptidase, lysis and entry