Figure 1 (Upper left) Stylized section of the adenovirus particle. For the description of the capsid (II, III, IIIa, IV, VI, VIII, IX) and core proteins (V, VII, X, Terminal), see text. As the structure of the nucleoprotein core has not been established, the polypeptides associated with the DNA are shown in hypothetical locations. (Lower left) Schematic diagram of the 12 hexons in one of the 20 facets (top view), each represented as a triangular “tower” superimposed on a pseudohexagonal base. There are four variants of hexon in the capsid, each with different environments (1-4). The two edge hexons from the three adjacent facets are shaded. Three vertex pentons are indicated in the diagram (Upper left and lower left adapted from Stewart, P.L. and Burnett, R.M.); (Right) Negative contrast electron micrograph of particles of a human adenovirus. The bar represents 100 nm.
Figure 2 Schematic of the transcription pattern of Human adenovirus 2 (HAdV-2). The parallel lines indicate the linear duplex genome of 36 kbp. The dots, broken lines and split arrows indicate the spliced structures of the mRNAs. E1A, E3, etc., refer to early transcription units. Most (but not all) late genes are in the major late transcription unit which initiates at map position 16 of the indicated top strand, and which includes the L1, L2, L3, L4 and L5 families of mRNAs. Other (intermediate) genes include those starred. (Adapted from Wold and Gooding, 1991.)
Figure 3 Phylogenetic tree of adenoviruses based on distance matrix analysis of the available protease (amino acid) sequences. The Seqboot (bootstrap), Protdist (Dayhoff PAM 001 matrix), Fitch (global rearrangements), and Consense programs of the PHYLIP 3.5c package were applied. Unrooted tree, the proposed atadenoviruses were chosen as outgroup. The names of the genera are shown and the proposed genus is in parenthesis. The species designations are printed in bold on the right side and the proposed species names of the unassigned viruses of the family are in parenthesis. Bootstrap values are shown below the nodes. The relative order of EAdV-2 and PAdV-3 was not confirmed by the bootstrap calculations (the actual bootstrap value is shown in parenthesis).
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