Taxonomic Structure of the Subfamily
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Subfamily |
Betaherpesvirinae |
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Genus |
Cytomegalovirus |
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Genus |
Muromegalovirus |
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Genus |
Roseolovirus |
Nucleotide sequences or predicted amino acid sequences of the subfamily members form a distinct lineage within the family. Genes corresponding to the HHV-5 US22 gene family are characteristic of the subfamily. The viruses tend to be species-specific and cell-type specific in culture. The growth cycle is slow and virus tends to remain cell associated. Infection is often clinically inapparent in immune-competent hosts. In some instances latent infection has been associated with cells of the monocyte series.
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