Taxonomic Structure of the Subfamily
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Subfamily |
Alphaherpesvirinae |
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Genus |
Simplexvirus |
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Genus |
Varicellovirus |
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Genus |
“Marek’s Disease-like Viruses” |
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Genus |
“Infectious Laryngotracheitis-like Viruses” |
The nucleotide sequences or predicted amino acid sequences of the subfamily members form a distinct lineage within the family. A region of the genome comprising the unique short sequence (US) and flanking inverted repeats (IRS and TRS) contains genes homologous to those found in HHV-1 and characteristic of the subfamily. The viruses productively infect fibroblasts in culture and epithelial cells in vivo. Many members cause overt, usually vesicular epithelial lesions in their natural hosts.
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