Figure 1 Herpesvirus morphology. (Top left) Reconstruction of a Human herpesvirus 1 (HHV-1) capsid generated from cryo-EM images. (Bottom left) Cartoon of one of the twenty icosahedral faces. Penton subunits are shown in black, hexon subunits in white and the pattern of triplexes and their connections with adjacent capsomers, in gray (Zhou, Chiu, Haskell, Spears, Jakana, Rixon and Scott, 1996). (Center) Schematic representation of a virion with diameters in nm. (G) genome, (C) capsid, (T) tegument, (E) envelope. (Right) Cryo-EM image of an HHV-1 virion. (Courtesy of Dr. Frazer Rixon and Dr. Wah Chiu.)
Figure 2 Simplified illustration of herpesvirus genome structures. Unique and repeated sequences are shown as solid lines and rectangles respectively. The orientations of repeated sequences are indicated by arrows. The nomenclature used to describe regions of type 3 and 4 genomes is shown: UL = Unique Long; US = Unique Short. The repeated sequences flanking the unique regions are named ‘terminal repeat short’ (TRS) and ‘internal repeat short’ (IRS) etc.
Figure 3 Organization of conserved gene blocks in members of different herpesvirus subfamilies. Prototype arrangements are shown of Human herpesvirus 1 (HHV-1) (Alphaherpesvirinae), Human herpesvirus 5 (HHV-5) (Betaherpesvirinae) and Human herpesvirus 4 (HHV-4) (Gammaherpesvirinae). Seven conserved gene blocks are shown and are identified by their UL ORF numbers in HHV-1. Examples of genes in each block are indicated. UDG = Uracil-DNA glycosylase; gL, gM, gH = glycoproteins L, M, H; h/p = subunit of the helicase-primase complex; pol = catalytic subunit of DNA polymerase; SSBP = single stranded DNA binding protein; RR = ribonucleotide reductase; MCP = major capsid protein; LTeg = large tegument protein. (Adapted from Gompels, Nicholas, Lawrence, Jones, Thomson, Martin, Efstathiou, Craxton and Macaulay, 1995).
Figure 4 Schematic representation of the replication of Human herpesvirus 1 (HHV-1) in permissive cells. (From Roizman and Sears, 1990.)
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